Professor Zhang Luo: Severe Rhinitis and Chronic Rhinosinusitis Specialist
Professor Zhang Luo is a senior otolaryngologist, professor, doctoral supervisor, and leading rhinology specialist associated with Beijing Tongren Hospital. His clinical and academic work focuses on allergic rhinitis, chronic rhinosinusitis with nasal polyps, nasal endoscopic surgery, airway inflammation, biologic therapies, and precision treatment for severe uncontrolled nasal disease.
Clinical and Academic Focus
- moderate-to-severe allergic rhinitis;
- chronic rhinosinusitis with nasal polyps;
- recurrent polyps after sinus surgery;
- nasal endoscopic surgery;
- type 2 airway inflammation;
- biologic treatment for severe disease;
- asthma and aspirin-exacerbated respiratory disease;
- smell loss and chronic nasal obstruction; and
- second opinions for difficult-to-control rhinologic disease.
Allergic Rhinitis
Allergic rhinitis can cause sneezing, itching, watery discharge, nasal blockage, poor sleep, fatigue, and reduced concentration. Triggers may be seasonal or present year-round.
Evaluation can include symptom pattern, nasal examination, skin-prick testing, serum allergen-specific IgE, and assessment for asthma, eczema, sinus disease, and sleep problems.
Treatment may include allergen reduction, saline irrigation, intranasal corticosteroids, antihistamines, leukotriene modifiers in selected patients, and allergen immunotherapy when appropriate.
Chronic Rhinosinusitis With Nasal Polyps
Chronic rhinosinusitis with nasal polyps can cause persistent blockage, smell loss, facial pressure, drainage, and recurrent infection-like symptoms. Diagnosis usually requires symptoms plus nasal endoscopy or CT evidence.
Treatment commonly begins with saline irrigation and topical corticosteroids. Short courses of systemic corticosteroids, surgery, antibiotics for selected infections, or biologic therapy may be considered according to disease pattern and severity.
Nasal Endoscopic Surgery
Endoscopic sinus surgery opens obstructed drainage pathways, removes inflammatory tissue when necessary, and improves delivery of topical medicine. It controls disease but does not remove the underlying tendency toward inflammation.
Long-term postoperative irrigation, topical treatment, endoscopic follow-up, and management of asthma or allergy are important for reducing recurrence.
Biologic Therapy
Biologic medicines target specific inflammatory pathways and may be considered for severe uncontrolled nasal-polyps disease, especially with repeated surgery, frequent systemic steroid use, asthma, or major smell loss.
Professor Zhang led major clinical research on stapokibart, an antibody targeting the IL-4 receptor alpha pathway, for severe uncontrolled chronic rhinosinusitis with nasal polyps.
Biologic availability, approval, cost, dosing, and eligibility vary. Response should be monitored and treatment reassessed rather than assumed to be permanent.
Type 2 Inflammation
Many patients with nasal polyps have type 2 inflammation involving eosinophils, IgE, and cytokines such as IL-4, IL-5, and IL-13. Biomarkers can support treatment planning but do not replace clinical assessment.
Asthma and Aspirin-Exacerbated Respiratory Disease
Nasal polyps can coexist with asthma and respiratory reactions to aspirin or other NSAIDs. These patients may have more severe recurrence and benefit from coordinated ear, nose and throat, allergy, and pulmonary care.
Patients with suspected aspirin sensitivity should not test themselves outside a supervised medical setting.
Loss of Smell
Smell loss may result from nasal inflammation, viral infection, neurological disease, medication, trauma, or tumor. In chronic sinus disease, treatment of inflammation may improve smell, but recovery varies.
Who May Consider a Consultation?
- patients with severe allergic rhinitis despite standard treatment;
- patients with chronic sinusitis and nasal polyps;
- patients with recurrent polyps after one or more surgeries;
- patients dependent on repeated systemic corticosteroids;
- patients considering biologic treatment;
- patients with nasal polyps plus asthma or aspirin sensitivity;
- patients with persistent smell loss or nasal obstruction; or
- patients seeking a second opinion before revision sinus surgery.
Medical Records to Prepare
- a concise symptom and treatment timeline;
- sinus CT in original DICOM format;
- nasal endoscopy images and videos;
- all previous sinus and nasal operative reports;
- pathology and culture results;
- allergy testing, eosinophil counts, total IgE, and other inflammatory markers;
- asthma testing and pulmonary records;
- smell-testing results when available;
- a complete list of nasal sprays, steroids, biologics, antibiotics, and other medicines; and
- a clear list of symptom and treatment goals.
Planning an International Consultation
Sudden vision change, eye swelling, severe headache, neurological symptoms, high fever, or rapidly worsening one-sided nasal symptoms requires urgent local assessment.
Stable patients should confirm whether CT, endoscopy, pathology, and allergy records can be reviewed. Remote medical-record review requires physician authorization. Final surgery or biologic eligibility usually requires in-person nasal endoscopy and clinical evaluation.
How CMCS Can Assist
CMCS – China Medical Concierge Shanghai is an independent medical concierge and health management company, not a hospital. We assist international patients with organizing and translating rhinology records, identifying an appropriate specialist, requesting appointment availability, arranging interpretation, and planning medical travel in China.
Access to Professor Zhang, remote review, surgery, biologic therapy, or a particular medicine is subject to doctor and hospital approval. CMCS does not guarantee appointments, treatment eligibility, medicine availability, or clinical outcomes.
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Important Note
Doctor titles, clinical roles, medicines, procedures, approvals, and appointment arrangements may change. This profile is based on the supplied verified research document and is for general information only. It does not replace assessment by a qualified rhinology and allergy team.
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