About Dr. Shi Si
Dr. Shi Si (施思) is an Associate Chief Physician (副主任医师) in the Department of Pancreatic Surgery at Fudan University Shanghai Cancer Center (FUSCC), one of China's leading dedicated cancer hospitals. A clinician-scientist with a strong translational research background, Dr. Shi has made significant contributions to the staging and individualized treatment of pancreatic cancer — most notably through the development of the “Shanghai Fudan” staging system, a refined classification framework designed to better stratify pancreatic cancer patients and guide treatment decisions.
Dr. Shi's work bridges the gap between laboratory discovery and clinical application. His research into the tumor microenvironment — specifically the role of stromal (connective tissue) composition in predicting chemotherapy response — has led to a novel, individualized approach to chemotherapy selection based on each patient's tumor stroma ratio. This precision oncology strategy represents a meaningful advance beyond one-size-fits-all chemotherapy protocols.
Clinical Expertise
- Minimally invasive pancreatic surgery — laparoscopic and robotic-assisted pancreaticoduodenectomy, distal pancreatectomy, and central pancreatectomy with reduced surgical trauma and faster recovery
- “Shanghai Fudan” staging system — a refined staging framework for pancreatic cancer that improves upon conventional TNM staging by incorporating tumor biology and resectability criteria for more accurate prognosis and treatment planning
- Stroma ratio-based individualized chemotherapy — using the proportion of tumor stroma (desmoplastic reaction) in biopsy or surgical specimens to guide chemotherapy regimen selection, optimizing efficacy and minimizing unnecessary toxicity
- Neoadjuvant and adjuvant therapy coordination — designing pre- and post-operative chemotherapy strategies tailored to individual tumor biology and staging
- Pancreatic cancer precision oncology — integrating molecular profiling, tumor microenvironment analysis, and genomic data into individualized treatment planning
- Multidisciplinary treatment — collaborating within FUSCC's tumor board to coordinate surgery, systemic therapy, and supportive care
Why Dr. Shi Si?
Dr. Shi Si represents a new generation of pancreatic cancer specialists who combine surgical skill with deep scientific expertise. For international patients seeking not just surgery but a truly individualized treatment strategy, Dr. Shi's approach offers something distinctive: a treatment plan informed by the specific biological characteristics of their tumor, not just its size and stage.
The “Shanghai Fudan” staging system he helped develop provides a more granular assessment of resectability and prognosis than standard TNM staging, which can be particularly valuable for patients with borderline or locally advanced disease where the decision to operate is nuanced. Similarly, his stroma ratio-based chemotherapy selection offers a rational, evidence-based framework for choosing between FOLFIRINOX, gemcitabine-based regimens, or other combinations — a decision that is often made empirically elsewhere.
His expertise in minimally invasive pancreatic surgery also means that eligible patients can benefit from laparoscopic or robotic resection, with shorter hospital stays, less postoperative pain, and faster return to systemic therapy if needed.
Hospital: Fudan University Shanghai Cancer Center (FUSCC)
FUSCC is China's premier dedicated cancer hospital, affiliated with Fudan University School of Medicine. It is consistently ranked among the top oncology centers in Asia, with internationally trained specialists, state-of-the-art surgical technology including the da Vinci Xi robotic system, and an active clinical trials program. The Pancreatic Surgery Department at FUSCC — led by Prof. Yu Xianjun — is one of the highest-volume and most research-active pancreatic surgery programs in China, making it an ideal environment for clinician-scientists like Dr. Shi to translate research into patient care.
About Pancreatic Cancer Staging & Individualized Treatment
Accurate staging is the foundation of effective pancreatic cancer treatment. Conventional TNM staging, while widely used, has limitations in capturing the full biological complexity of pancreatic tumors. Key concepts for international patients:
- Resectability classification: pancreatic cancers are classified as resectable, borderline resectable, locally advanced, or metastatic — each requiring a different treatment strategy
- Tumor stroma: pancreatic cancer is characterized by a dense desmoplastic stroma that impairs drug delivery and promotes treatment resistance; the proportion of stroma relative to tumor cells varies between patients and influences chemotherapy response
- FOLFIRINOX vs. gemcitabine + nab-paclitaxel: the two main first-line chemotherapy regimens have different mechanisms of action and toxicity profiles; stroma ratio analysis may help identify which patients benefit most from each
- Molecular profiling: KRAS, BRCA1/2, PALB2, ATM, and MSI/MMR status are increasingly used to guide targeted therapy and immunotherapy decisions
- Minimally invasive surgery outcomes: robotic and laparoscopic pancreatic resections at high-volume centers achieve equivalent oncological outcomes to open surgery with significantly reduced morbidity
What to Prepare Before Your Consultation
To enable Dr. Shi's team to conduct a thorough remote case review, international patients should prepare:
- CT scan of the abdomen and pelvis with contrast (DICOM format, within 3 months)
- MRI/MRCP if available
- Pathology report and biopsy results, including any available immunohistochemistry or molecular profiling
- CA 19-9, CEA, and other relevant tumor markers
- Summary of prior treatments and response assessments
- Genetic testing results (BRCA1/2, PALB2, KRAS, MSI/MMR) if available
- Current performance status and nutritional assessment
How CMCS Can Help
China Medical Concierge Shanghai (CMCS) coordinates access to Dr. Shi Si and the FUSCC pancreatic surgery team for international patients. Our services include:
- Remote case review and pre-consultation assessment before you travel
- Priority appointment scheduling with Dr. Shi's team at FUSCC
- Full translation of medical records, imaging reports, pathology, and treatment plans
- In-hospital accompaniment by a dedicated English-speaking case manager
- Accommodation, airport transfer, and logistics coordination in Shanghai
- Post-discharge follow-up and remote consultation support after returning home
Contact us to begin your case review:
📧 contract@medicalsh.com
💬 WhatsApp: https://wa.me/message/3AM6KAGCW2BAD1
🌐 www.medicalsh.com
0 則留言