Reproductive Medicine & IVF at Renji Hospital Shanghai | CMCS

Expert Fertility Treatment & Assisted Reproduction in Shanghai

The Department of Reproductive Medicine at Renji Hospital — affiliated with Shanghai Jiao Tong University School of Medicine — is one of Shanghai's most distinguished and highest-volume fertility centers, with a national reputation for excellence in in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation genetic testing (PGT), fertility preservation, and the management of complex infertility conditions. The department combines outstanding clinical expertise with a world-class embryology laboratory and a fully integrated multidisciplinary approach, offering international patients access to some of China's most eminent reproductive medicine specialists and the latest assisted reproductive technologies.

For international patients seeking fertility treatment in Shanghai — whether for IVF, ICSI, PGT for genetic conditions, fertility preservation before cancer treatment, or expert management of recurrent implantation failure or recurrent pregnancy loss — Renji Hospital's reproductive medicine department offers an unparalleled combination of clinical expertise, laboratory excellence, and research leadership. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international patients throughout their fertility treatment journey at Renji Hospital.

About the Department

Renji Hospital's reproductive medicine department is a nationally accredited ART (assisted reproductive technology) center operating a comprehensive fertility clinic, a state-of-the-art IVF laboratory with time-lapse embryo monitoring, a PGT laboratory with next-generation sequencing capabilities, a fertility preservation program, a recurrent pregnancy loss clinic, a male fertility clinic, and works in close collaboration with gynecology, urology, genetics, and endocrinology through a fully integrated multidisciplinary team.

Faculty members publish regularly in leading reproductive medicine journals including Human Reproduction, Fertility and Sterility, Journal of Clinical Endocrinology & Metabolism, Reproductive BioMedicine Online, and Human Reproduction Update.

Assisted Reproductive Technologies

In Vitro Fertilization (IVF)

IVF is the cornerstone of Renji Hospital's reproductive medicine program, with one of the highest IVF cycle volumes in Shanghai:

• Controlled Ovarian Stimulation (COS) — Individualized stimulation protocols based on ovarian reserve (AMH, AFC); GnRH agonist long protocol; GnRH antagonist protocol; mild stimulation; natural cycle IVF; PCOS-tailored protocols
• Egg Retrieval — Ultrasound-guided transvaginal oocyte retrieval under sedation; experienced embryologists for optimal oocyte handling
• Embryo Culture — Extended blastocyst culture to day 5/6; time-lapse embryo monitoring (EmbryoScope) for non-invasive embryo selection; sequential and single-step culture media
• Embryo Transfer — Fresh and frozen embryo transfer (FET); ultrasound-guided transfer; single embryo transfer (SET) policy to minimize multiple pregnancy risk; endometrial preparation protocols
• Freeze-All Strategy — Elective embryo cryopreservation for OHSS risk, endometrial receptivity optimization, and PGT cycles; vitrification with high survival rates

Intracytoplasmic Sperm Injection (ICSI)

• Standard ICSI — For male factor infertility, prior fertilization failure, and low sperm count/motility/morphology
• Physiological ICSI (PICSI) — Hyaluronan-binding sperm selection for improved embryo quality
• IMSI (Intracytoplasmic Morphologically Selected Sperm Injection) — High-magnification sperm selection for severe male factor
• Laser-Assisted Hatching — For poor prognosis patients and frozen embryo transfers

Preimplantation Genetic Testing (PGT)

Renji Hospital's PGT program is one of the most comprehensive in Shanghai, offering all three types of PGT:

• PGT-A (Aneuploidy Screening) — Next-generation sequencing (NGS)-based comprehensive chromosomal screening of all 24 chromosomes; identification of euploid embryos for transfer; recommended for advanced maternal age, recurrent miscarriage, and recurrent implantation failure
• PGT-M (Monogenic Disease) — Single gene disorder testing for couples at risk of transmitting a specific genetic condition; custom probe design for each family; conditions include cystic fibrosis, spinal muscular atrophy, thalassemia, sickle cell disease, BRCA1/2, Huntington disease, fragile X syndrome, and hundreds of other monogenic conditions
• PGT-SR (Structural Rearrangements) — For couples carrying chromosomal translocations, inversions, or other structural rearrangements; identification of balanced or normal embryos for transfer
• PGT-HLA (HLA Matching) — For couples who need a HLA-matched sibling donor for an existing child with a serious hematological condition (e.g., thalassemia, aplastic anemia, leukemia); savior sibling program

Surgical Sperm Retrieval

• TESA (Testicular Sperm Aspiration) — For obstructive azoospermia; needle aspiration of testicular tissue
• TESE (Testicular Sperm Extraction) — Open testicular biopsy for sperm retrieval
• Micro-TESE (Microsurgical TESE) — Operating microscope-guided testicular sperm extraction for non-obstructive azoospermia; highest sperm retrieval rates for NOA
• PESA (Percutaneous Epididymal Sperm Aspiration) — For obstructive azoospermia due to vas deferens obstruction or prior vasectomy

Fertility Preservation

Oncofertility — Fertility Preservation Before Cancer Treatment

Renji Hospital's oncofertility program provides urgent fertility preservation for patients facing gonadotoxic cancer treatment:

• Emergency Oocyte Cryopreservation — Rapid ovarian stimulation and egg freezing before chemotherapy or radiation; random-start protocols for urgent cases; 2-week turnaround from consultation to egg retrieval
• Emergency Embryo Cryopreservation — IVF and embryo freezing for patients with a partner before cancer treatment
• Ovarian Tissue Cryopreservation — Laparoscopic ovarian cortex removal and cryopreservation for prepubertal girls and patients who cannot delay cancer treatment; ovarian tissue reimplantation after cancer cure
• GnRH Agonist Ovarian Suppression — Leuprolide during chemotherapy for ovarian protection in premenopausal women with hormone-receptor negative cancers
• Sperm Cryopreservation — For male patients before gonadotoxic treatment; same-day processing
• Testicular Tissue Cryopreservation — For prepubertal boys before gonadotoxic treatment; experimental

Elective Fertility Preservation

• Elective Egg Freezing — Social egg freezing for women wishing to delay childbearing; age-appropriate counseling on success rates
• Embryo Banking — For couples wishing to preserve embryos for future use
• Sperm Banking — For men wishing to preserve fertility before vasectomy or for other personal reasons

Specialized Fertility Clinics

Recurrent Implantation Failure (RIF) Clinic

For patients who have failed three or more good-quality embryo transfers without achieving pregnancy:

• Endometrial receptivity assessment (ERA test) for personalized embryo transfer timing
• Endometrial microbiome analysis (EMMA/ALICE) for chronic endometritis detection
• Hysteroscopy for uterine cavity assessment and treatment
• Immunological evaluation and treatment (IVIG, intralipid, prednisolone, tacrolimus)
• Thrombophilia screening and anticoagulation
• Sperm DNA fragmentation testing and ICSI optimization
• PGT-A for euploid embryo selection

Recurrent Pregnancy Loss (RPL) Clinic

For patients with two or more pregnancy losses:

• Chromosomal analysis of both partners (karyotype)
• Products of conception (POC) chromosomal analysis
• Antiphospholipid syndrome (APS) testing and treatment (aspirin + LMWH)
• Thrombophilia panel
• Uterine anatomy assessment (3D ultrasound, hysteroscopy, MRI)
• Thyroid function and autoimmune evaluation
• PGT-A for euploid embryo selection
• Progesterone supplementation protocols

Polycystic Ovary Syndrome (PCOS) Fertility Clinic

• Letrozole ovulation induction (first-line)
• Clomiphene citrate
• Metformin for insulin-resistant PCOS
• Gonadotropin ovulation induction with careful monitoring
• IVF with freeze-all strategy to minimize OHSS risk
• Dopamine agonist (cabergoline) for OHSS prevention
• In vitro maturation (IVM) for severe PCOS to avoid OHSS

Male Fertility Clinic

• Comprehensive semen analysis and sperm function testing
• Sperm DNA fragmentation (SDF) testing
• Hormonal evaluation (FSH, LH, testosterone, prolactin)
• Scrotal ultrasound for varicocele and structural abnormalities
• Varicocele repair coordination with urology
• Genetic testing (karyotype, Y chromosome microdeletion, CFTR for CBAVD)
• Micro-TESE for non-obstructive azoospermia

Diminished Ovarian Reserve (DOR) Clinic

• AMH and AFC assessment
• Individualized stimulation protocols for poor responders (Bologna criteria)
• Dual stimulation (DuoStim) for maximum oocyte yield in poor responders
• Adjuvant therapies: growth hormone, DHEA, CoQ10
• Egg donation counseling for very poor responders

Why International Patients Choose Renji Reproductive Medicine

• High-Volume IVF Program — One of Shanghai's highest-volume IVF centers with competitive live birth rates
• Comprehensive PGT — PGT-A, PGT-M, PGT-SR, and PGT-HLA (savior sibling) under one roof
• Oncofertility Expertise — Emergency fertility preservation for cancer patients with rapid turnaround
• RIF & RPL Specialization — Systematic evaluation and treatment for patients with repeated IVF failure or miscarriage
• Micro-TESE Program — Expert surgical sperm retrieval for non-obstructive azoospermia
• Cost-Effectiveness — World-class IVF and fertility treatment at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your fertility history, prior IVF cycles, semen analysis, AMH, AFC, and relevant medical history with CMCS.
2. Medical Record Preparation — We translate and organize your records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate reproductive medicine specialist based on your diagnosis — IVF, PGT, oncofertility, RIF, RPL, or male factor.
4. Cycle Planning — We coordinate your treatment cycle timing with Renji's reproductive medicine team, including pre-cycle investigations and medication protocols.
5. Priority Scheduling — We secure a consultation and treatment slot with minimal waiting time.
6. Travel & Logistics — Assistance with visa invitation letters, accommodation near Renji Hospital for the duration of your treatment cycle, and Shanghai airport transfers.
7. On-Site Concierge — Bilingual coordinators accompany you throughout monitoring appointments, egg retrieval, and embryo transfer, managing translation and communication.
8. Post-Transfer Follow-Up — Pregnancy test coordination, early pregnancy monitoring, and remote follow-up after you return home.

Book a Consultation

If you are seeking expert fertility treatment in Shanghai — whether for IVF, ICSI, PGT, fertility preservation, or management of recurrent implantation failure or pregnancy loss — CMCS can arrange a specialist consultation with Renji Hospital's reproductive medicine team.

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