Pediatric Neurology at Fudan University Children's Hospital Shanghai | CMCS

Expert Child Brain & Nervous System Care at China's Premier Children's Hospital

The Department of Neurology at Fudan University Children's Hospital (FUCH) is one of China's most distinguished pediatric neurology centers, with a national reputation for excellence in the diagnosis and management of childhood epilepsy, rare neurological diseases, neuromuscular disorders, metabolic and mitochondrial diseases, autoimmune neurological conditions, and neurodevelopmental disorders. The department combines outstanding clinical expertise with a world-class research program and a fully integrated multidisciplinary approach, offering international families access to some of China's most eminent pediatric neurologists and the latest evidence-based treatments for complex childhood neurological conditions.

For international families with a child with epilepsy, a rare neurological disease, a neuromuscular disorder, or a complex neurological diagnosis that has eluded physicians elsewhere — FUCH's neurology department represents one of the most compelling destinations in Asia. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international families throughout their child's care journey at FUCH.

About the Department

FUCH's neurology department is a national key clinical specialty operating dedicated pediatric neurology inpatient wards, a comprehensive outpatient neurology clinic, a video-EEG monitoring unit, an epilepsy surgery program, a neuromuscular disease clinic, a metabolic and mitochondrial disease clinic, an autoimmune neurology clinic, a neurodevelopmental assessment center, and a neurogenetics laboratory. The department works in close collaboration with neurosurgery, neuroradiology, neurophysiology, genetics, and rehabilitation medicine through a fully integrated multidisciplinary team.

Faculty members publish regularly in leading pediatric neurology journals including Annals of Neurology, Neurology, Brain, Epilepsia, Journal of Child Neurology, and European Journal of Paediatric Neurology.

Conditions Treated

Epilepsy & Seizure Disorders

• Focal Epilepsy — Comprehensive video-EEG evaluation; MRI-guided seizure focus localization; anti-seizure medication (ASM) optimization; epilepsy surgery evaluation for drug-resistant focal epilepsy
• Generalized Epilepsy Syndromes — Childhood absence epilepsy; juvenile myoclonic epilepsy; juvenile absence epilepsy; ASM selection based on syndrome and EEG pattern
• Infantile Spasms (West Syndrome) — ACTH and vigabatrin; prednisolone; ketogenic diet; TSC-associated infantile spasms: everolimus
• Lennox-Gastaut Syndrome — Valproate, lamotrigine, rufinamide, clobazam; fenfluramine; cannabidiol (Epidiolex); corpus callosotomy; VNS
• Dravet Syndrome — Valproate + clobazam; stiripentol; fenfluramine; cannabidiol; SCN1A mutation-guided management; avoidance of sodium channel blockers
• KCNQ2 & Other Neonatal Epilepsies — Genetic diagnosis; carbamazepine for KCNQ2 gain-of-function; phenobarbital
• Tuberous Sclerosis Complex (TSC) — Everolimus for TSC-associated epilepsy, SEGA, and renal angiomyolipoma; epilepsy surgery for drug-resistant TSC epilepsy
• CDKL5 Deficiency Disorder — Ganaxolone; ASM combinations; ketogenic diet
• Drug-Resistant Epilepsy — Comprehensive presurgical evaluation (video-EEG, MRI, PET, SPECT, MEG, stereo-EEG); epilepsy surgery; VNS; ketogenic diet; responsive neurostimulation (RNS)

Epilepsy Surgery Program

• Resective Surgery — Temporal lobectomy; extratemporal resection; lesionectomy for focal cortical dysplasia, cavernoma, and tumor-associated epilepsy
• Stereo-EEG (SEEG) — Minimally invasive intracranial electrode implantation for seizure focus localization in non-lesional and complex epilepsy
• Laser Interstitial Thermal Therapy (LITT) — Minimally invasive laser ablation for hypothalamic hamartoma, focal cortical dysplasia, and other epileptogenic lesions
• Hemispherectomy & Hemispherotomy — For hemispheric epilepsy syndromes (Rasmussen encephalitis, Sturge-Weber, large MCA infarct)
• Corpus Callosotomy — For drop attacks in Lennox-Gastaut syndrome
• Vagus Nerve Stimulation (VNS) — For drug-resistant epilepsy not amenable to resective surgery

Neuromuscular Diseases

• Spinal Muscular Atrophy (SMA) — Nusinersen (intrathecal); onasemnogene abeparvovec (Zolgensma) gene therapy for SMA type 1 under 2 years; risdiplam (oral) for all SMA types; respiratory and nutritional support
• Duchenne Muscular Dystrophy (DMD) — Corticosteroids (deflazacort, vamorolone); exon-skipping therapies (eteplirsen for exon 51, golodirsen for exon 53, viltolarsen for exon 53, casimersen for exon 45); ataluren for nonsense mutations; cardiac and respiratory monitoring; gene therapy clinical trials
• Congenital Muscular Dystrophies — Merosin-deficient CMD; LAMA2-related CMD; SELENON-related CMD; multidisciplinary supportive care
• Congenital Myopathies — Nemaline myopathy, central core disease, and other congenital myopathies; genetic diagnosis and supportive care
• Pompe Disease (Glycogen Storage Disease Type II) — Enzyme replacement therapy (alglucosidase alfa, avalglucosidase alfa); miglustat as chaperone therapy
• Myasthenia Gravis (Juvenile) — Pyridostigmine; corticosteroids; azathioprine; rituximab; eculizumab for refractory generalized MG; ravulizumab; efgartigimod; thymectomy coordination
• Guillain-Barré Syndrome — IVIG and plasmapheresis; respiratory monitoring; rehabilitation
• Charcot-Marie-Tooth Disease — Genetic diagnosis; orthotic management; rehabilitation

Metabolic & Mitochondrial Diseases

• Phenylketonuria (PKU) — Phenylalanine-restricted diet; sapropterin (BH4) for BH4-responsive PKU; pegvaliase for adults; PEGylated phenylalanine ammonia lyase
• Organic Acidemias — Methylmalonic acidemia, propionic acidemia, isovaleric acidemia; dietary management; carnitine supplementation; liver transplantation for selected cases
• Urea Cycle Disorders — Protein restriction; nitrogen scavengers (sodium benzoate, sodium phenylbutyrate, glycerol phenylbutyrate); liver transplantation
• Fatty Acid Oxidation Disorders — MCAD, VLCAD, and LCHAD deficiency; dietary management; carnitine supplementation
• Lysosomal Storage Diseases — Gaucher disease (imiglucerase, velaglucerase, eliglustat); Fabry disease (agalsidase, migalastat); MPS I, II, IVA, VI (enzyme replacement therapy); Niemann-Pick type C (miglustat)
• Mitochondrial Diseases — MELAS, MERRF, Leigh syndrome, POLG-related disorders; mitochondrial cocktail; idebenone for Leber hereditary optic neuropathy; clinical trials for novel mitochondrial therapies
• Neuronal Ceroid Lipofuscinoses (NCL) — Cerliponase alfa (Brineura) for CLN2 disease; supportive care for other NCL forms
• Wilson's Disease — D-penicillamine, trientine, and zinc; liver transplantation for fulminant hepatic failure

Autoimmune Neurological Diseases

• Autoimmune Encephalitis — Anti-NMDAR, anti-LGI1, anti-CASPR2, and other autoimmune encephalitides; first-line immunotherapy (IVIG, methylprednisolone, plasmapheresis); second-line (rituximab, cyclophosphamide); maintenance immunosuppression
• Pediatric Multiple Sclerosis — High-efficacy DMTs (natalizumab, ocrelizumab, ofatumumab) preferred for pediatric MS; fingolimod; cladribine
• NMOSD & MOGAD — AQP4-IgG and MOG-IgG testing; inebilizumab, satralizumab, and eculizumab for AQP4-positive NMOSD; IVIG for MOGAD attacks
• Opsoclonus-Myoclonus-Ataxia Syndrome — ACTH; rituximab; cyclophosphamide; neuroblastoma workup
• Sydenham's Chorea — Penicillin prophylaxis; valproate and carbamazepine for chorea; IVIG for severe cases

Neurodevelopmental Disorders

• Autism Spectrum Disorder (ASD) — Comprehensive diagnostic evaluation; genetic testing (chromosomal microarray, WES); behavioral and educational intervention coordination; risperidone and aripiprazole for irritability
• Attention Deficit Hyperactivity Disorder (ADHD) — Methylphenidate, amphetamine salts, and atomoxetine; behavioral therapy coordination
• Intellectual Disability — Genetic diagnosis; early intervention coordination; fragile X syndrome (minocycline, metformin in trials)
• Cerebral Palsy — Spasticity management (botulinum toxin, intrathecal baclofen); selective dorsal rhizotomy; rehabilitation coordination
• Rett Syndrome — Trofinetide (Daybue); supportive care; MECP2 gene therapy in clinical trials
• Angelman Syndrome — Genetic diagnosis; seizure management; gene therapy clinical trials

Stroke & Cerebrovascular Disease in Children

• Arterial Ischemic Stroke — Acute thrombolysis and thrombectomy for selected cases; antiplatelet and anticoagulation therapy; underlying cause investigation
• Cerebral Sinovenous Thrombosis — Anticoagulation; underlying cause management
• Moyamoya Disease — Surgical revascularization (STA-MCA bypass, EDAS) in collaboration with neurosurgery
• Sickle Cell Disease Stroke — Chronic transfusion therapy; hydroxyurea; BMT

Ketogenic Diet Program

FUCH's ketogenic diet program is one of the most experienced in China for pediatric drug-resistant epilepsy, offering:

• Classic ketogenic diet (4:1 fat:carbohydrate+protein ratio)
• Modified Atkins diet for older children and adolescents
• Medium-chain triglyceride (MCT) diet
• Low glycemic index treatment (LGIT)
• Dedicated ketogenic diet dietitian and nursing support
• Remote monitoring and diet adjustment after discharge

Why International Families Choose FUCH Neurology

• Epilepsy Surgery Expertise — Comprehensive presurgical evaluation including SEEG and LITT for drug-resistant epilepsy
• SMA & DMD Treatment Leadership — Access to nusinersen, Zolgensma, risdiplam, and exon-skipping therapies for neuromuscular diseases
• Rare Metabolic Disease Expertise — Enzyme replacement therapy, dietary management, and liver transplantation coordination for lysosomal storage and metabolic diseases
• Autoimmune Encephalitis Program — Expert diagnosis and immunotherapy for anti-NMDAR and other autoimmune encephalitides
• Neurodevelopmental Assessment — Comprehensive genetic and developmental evaluation for ASD, intellectual disability, and rare neurodevelopmental syndromes
• Cost-Effectiveness — World-class pediatric neurology care at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your child's neurological history, EEG reports, MRI, genetic testing results, and current medications with CMCS.
2. Medical Record Preparation — We translate and organize your child's records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate pediatric neurologist based on your child's condition — epilepsy, neuromuscular disease, metabolic disease, autoimmune neurology, or neurodevelopmental disorder.
4. Priority Scheduling — We secure a consultation with minimal waiting time.
5. Travel & Logistics — Assistance with visa invitation letters, family accommodation near FUCH, and Shanghai airport transfers.
6. On-Site Concierge — Bilingual coordinators accompany your family throughout hospital visits, managing registration, translation, and communication.
7. Diagnostic Support — Full coordination of video-EEG monitoring, MRI, genetic testing, metabolic workup, and other required investigations.
8. Post-Consultation Follow-Up — Test result translation, treatment plan interpretation, and remote follow-up coordination after you return home.

Book a Consultation

If your child has epilepsy, a rare neurological disease, a neuromuscular disorder, a metabolic disease, or a complex neurological diagnosis — CMCS can arrange a specialist consultation with FUCH's pediatric neurology team in Shanghai.

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