Pediatric Endocrinology at Fudan University Children's Hospital Shanghai | CMCS

Expert Hormonal & Metabolic Care for Children at China's Premier Children's Hospital

The Department of Endocrinology at Fudan University Children's Hospital (FUCH) is one of China's most distinguished pediatric endocrinology centers, with a national reputation for excellence in the diagnosis and management of growth disorders, diabetes, thyroid disease, adrenal disorders, disorders of sex development, puberty disorders, and rare endocrine conditions in children. The department combines outstanding clinical expertise with a world-class research program and a fully integrated multidisciplinary approach, offering international families access to some of China's most eminent pediatric endocrinologists and the latest evidence-based treatments for complex childhood hormonal and metabolic conditions.

For international families with a child with short stature, growth hormone deficiency, type 1 diabetes, a disorder of sex development, precocious puberty, or a rare endocrine condition — FUCH's endocrinology department represents one of the most compelling destinations in Asia. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international families throughout their child's care journey at FUCH.

About the Department

FUCH's endocrinology department is a national key clinical specialty operating dedicated pediatric endocrinology inpatient wards, a comprehensive outpatient endocrinology clinic, a diabetes center with insulin pump and CGM programs, a growth clinic, a puberty clinic, a disorders of sex development (DSD) multidisciplinary team, an adrenal disorders clinic, and a bone and mineral metabolism clinic. The department works in close collaboration with genetics, urology, gynecology, neurosurgery, and nuclear medicine through a fully integrated multidisciplinary team.

Faculty members publish regularly in leading pediatric endocrinology journals including Journal of Clinical Endocrinology & Metabolism, Diabetes Care, Hormone Research in Paediatrics, European Journal of Endocrinology, and Clinical Endocrinology.

Conditions Treated

Growth Disorders

• Growth Hormone Deficiency (GHD) — Growth hormone stimulation testing (insulin tolerance test, glucagon test, arginine test); MRI for pituitary anatomy; recombinant human growth hormone (rhGH) therapy; long-acting growth hormone (somapacitan, lonapegsomatropin) for weekly dosing; IGF-1 monitoring
• Idiopathic Short Stature (ISS) — Growth velocity assessment; bone age; rhGH therapy for severe ISS; psychological support
• Small for Gestational Age (SGA) with Failure to Catch Up — rhGH therapy for persistent short stature after SGA birth
• Turner Syndrome — Karyotype confirmation; rhGH therapy; estrogen replacement for pubertal induction; cardiac and renal surveillance; fertility counseling
• Noonan Syndrome — PTPN11 and other RASopathy gene testing; rhGH therapy; cardiac surveillance
• SHOX Deficiency — SHOX gene testing; rhGH therapy
• Achondroplasia — FGFR3 mutation confirmation; vosoritide (C-type natriuretic peptide analogue) for linear growth improvement; limb lengthening coordination
• Skeletal Dysplasias — Genetic diagnosis; multidisciplinary management
• Tall Stature — Marfan syndrome; Sotos syndrome; sex steroid therapy for extreme tall stature

Diabetes

• Type 1 Diabetes (T1D) — Multiple daily injection (MDI) therapy; continuous subcutaneous insulin infusion (CSII/insulin pump); continuous glucose monitoring (CGM); hybrid closed-loop systems (artificial pancreas); carbohydrate counting education; hypoglycemia management; DKA prevention
• Type 2 Diabetes in Children & Adolescents — Lifestyle modification; metformin; GLP-1 receptor agonists (liraglutide, semaglutide) for adolescents; SGLT2 inhibitors for adolescents
• Monogenic Diabetes (MODY) — Genetic panel testing for GCK, HNF1A, HNF4A, HNF1B, and other MODY genes; sulfonylureas for HNF1A/HNF4A MODY; dietary management for GCK MODY; insulin for neonatal diabetes (KCNJ11, ABCC8)
• Neonatal Diabetes — KCNJ11 and ABCC8 mutation testing; transition from insulin to sulfonylurea for KATP channel mutations
• Cystic Fibrosis-Related Diabetes (CFRD) — Annual OGTT screening; insulin therapy
• Steroid-Induced Diabetes — Insulin therapy during steroid courses
• Diabetic Complications — Screening and management of nephropathy, retinopathy, and neuropathy

Thyroid Disorders

• Congenital Hypothyroidism — Newborn screening follow-up; levothyroxine optimization; neurodevelopmental monitoring
• Acquired Hypothyroidism (Hashimoto's Thyroiditis) — Levothyroxine therapy; TPO antibody monitoring
• Graves' Disease & Hyperthyroidism — Antithyroid drugs (methimazole, propylthiouracil); radioiodine; thyroidectomy for selected cases
• Thyroid Nodules & Cancer in Children — Ultrasound-guided FNA; thyroidectomy coordination; radioiodine; targeted therapy for advanced thyroid cancer
• Thyroid Dysgenesis & Ectopic Thyroid — Thyroid scintigraphy; levothyroxine therapy

Adrenal Disorders

• Congenital Adrenal Hyperplasia (CAH) — 21-hydroxylase deficiency; hydrocortisone and fludrocortisone optimization; growth and bone health monitoring; fertility management; tildrakizumab and crinecerfont (CRF1 receptor antagonist) for CAH in clinical trials
• Adrenal Insufficiency — Primary (Addison's disease) and secondary; hydrocortisone replacement; sick day rules; emergency management
• Cushing's Syndrome in Children — Urinary free cortisol; late-night salivary cortisol; low-dose DST; ACTH; pituitary MRI; adrenal CT; IPSS for Cushing's disease; transsphenoidal surgery coordination
• Pheochromocytoma & Paraganglioma — Plasma/urine metanephrines; MIBG scan; SDH mutation testing; alpha-blockade and surgical resection coordination
• Primary Hyperaldosteronism — Aldosterone-to-renin ratio; adrenal CT; adrenalectomy coordination

Puberty Disorders

• Central Precocious Puberty (CPP) — GnRH stimulation test; brain MRI; GnRH analogue therapy (leuprolide, triptorelin) for CPP; height outcome optimization
• Peripheral Precocious Puberty — McCune-Albright syndrome; familial male-limited precocious puberty; testotoxicosis; aromatase inhibitors and anti-androgens
• Delayed Puberty — Constitutional delay vs. hypogonadism; testosterone and estrogen induction; GnRH pump for hypogonadotropic hypogonadism; fertility counseling
• Hypogonadotropic Hypogonadism — Kallmann syndrome (KAL1, FGFR1, PROKR2); GnRH pump therapy; gonadotropin therapy for fertility
• Klinefelter Syndrome (47,XXY) — Testosterone replacement; fertility counseling; psychological support

Disorders of Sex Development (DSD)

• 46,XY DSD — Complete and partial androgen insensitivity syndrome (CAIS/PAIS); 5-alpha reductase deficiency; 17-beta HSD deficiency; gonadal dysgenesis; genetic diagnosis; multidisciplinary DSD team management
• 46,XX DSD — CAH; aromatase excess; gonadal dysgenesis
• Sex Chromosome DSD — Turner syndrome; Klinefelter syndrome; mixed gonadal dysgenesis
• DSD Multidisciplinary Team — Endocrinology, genetics, urology, gynecology, psychology, and ethics; individualized management; gender identity support

Bone & Mineral Metabolism

• Rickets — Nutritional rickets (vitamin D and calcium); X-linked hypophosphatemic rickets (burosumab — anti-FGF23 antibody); tumor-induced osteomalacia
• Hypoparathyroidism — Calcium and active vitamin D; PTH replacement (natpara)
• Hyperparathyroidism — Primary HPT; parathyroidectomy coordination; cinacalcet
• Osteoporosis in Children — Bisphosphonates for osteogenesis imperfecta and secondary osteoporosis; romosozumab in trials
• Osteogenesis Imperfecta — Pamidronate and zoledronic acid; setrusumab (anti-sclerostin) in clinical trials; orthopedic coordination
• Hypercalcemia — Williams syndrome; idiopathic infantile hypercalcemia (CYP24A1 mutations); hyperparathyroidism

Diabetes Technology Program

FUCH's diabetes technology program is one of the most advanced in China for pediatric patients:

• Continuous Glucose Monitoring (CGM) — Real-time CGM (Dexcom G7, Libre 3) for all T1D patients; time-in-range optimization; remote monitoring
• Insulin Pump Therapy (CSII) — Medtronic, Tandem, and Omnipod systems; pump initiation and optimization; sick day management
• Hybrid Closed-Loop Systems — Tandem Control-IQ; Medtronic 780G; DIY APS systems; artificial pancreas technology for optimal glucose control
• Structured Diabetes Education — Carbohydrate counting; sick day rules; hypoglycemia management; school and sports management

Why International Families Choose FUCH Endocrinology

• Growth Disorder Expertise — Comprehensive growth hormone stimulation testing; long-acting GH; vosoritide for achondroplasia
• Diabetes Technology Leadership — Hybrid closed-loop systems and CGM for optimal T1D management; MODY genetic diagnosis
• DSD Multidisciplinary Team — Comprehensive, individualized management of disorders of sex development
• CAH Expertise — Hydrocortisone optimization and emerging CRF1 receptor antagonist therapy
• Rare Endocrine Disease — Burosumab for XLH rickets; osteogenesis imperfecta bisphosphonate therapy
• Cost-Effectiveness — World-class pediatric endocrinology care at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your child's endocrine history, growth charts, hormone test results, imaging, genetic testing, and current medications with CMCS.
2. Medical Record Preparation — We translate and organize your child's records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate pediatric endocrinologist based on your child's condition — growth, diabetes, thyroid, adrenal, puberty, DSD, or bone metabolism.
4. Priority Scheduling — We secure a consultation with minimal waiting time.
5. Travel & Logistics — Assistance with visa invitation letters, family accommodation near FUCH, and Shanghai airport transfers.
6. On-Site Concierge — Bilingual coordinators accompany your family throughout hospital visits, managing registration, translation, and communication.
7. Diagnostic Support — Full coordination of growth hormone stimulation tests, dynamic endocrine function tests, imaging, and genetic testing.
8. Post-Consultation Follow-Up — Test result translation, treatment plan interpretation, and remote follow-up coordination after you return home.

Book a Consultation

If your child has a growth disorder, diabetes, thyroid disease, an adrenal condition, a puberty disorder, a disorder of sex development, or a rare endocrine condition — CMCS can arrange a specialist consultation with FUCH's pediatric endocrinology team in Shanghai.

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