Neurosurgery at Shanghai First People's Hospital | CMCS

Expert Neurosurgical Care at One of Shanghai's Premier Academic Medical Centers

The Department of Neurosurgery at Shanghai First People's Hospital — affiliated with Shanghai Jiao Tong University School of Medicine — is one of Shanghai's most distinguished neurosurgery centers, with a national reputation for excellence in brain tumor surgery, cerebrovascular surgery, functional neurosurgery, spinal neurosurgery, and the management of complex neurosurgical conditions. With state-of-the-art intraoperative MRI, neuronavigation, and awake craniotomy capability, the department combines outstanding surgical expertise with a world-class research program, offering international patients access to some of China's most eminent neurosurgeons. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international patients throughout their neurosurgical care journey.

About the Department

The neurosurgery department is a national key clinical specialty operating dedicated neurosurgery wards, a neurosurgical intensive care unit (NSICU), multiple operating theaters with intraoperative MRI (iMRI), neuronavigation, intraoperative neurophysiological monitoring (IONM), fluorescence-guided surgery (5-ALA), and awake craniotomy capability, a Gamma Knife radiosurgery center, a neuroendoscopy program, a functional neurosurgery program, and works in close collaboration with neurology, oncology, radiation oncology, and rehabilitation through a fully integrated multidisciplinary neuro-oncology tumor board.

Brain Tumor Surgery

Glioma

• Glioblastoma (GBM) — Maximal safe resection with awake craniotomy for eloquent area tumors; 5-ALA fluorescence-guided surgery for complete resection; intraoperative MRI for real-time resection control; temozolomide + radiation (Stupp protocol); tumor treating fields (TTFields — Optune); bevacizumab for recurrent GBM; EGFR amplification; MGMT methylation; IDH status; TERT promoter mutation; CDKN2A/B deletion; one of Shanghai's most experienced GBM programs
• IDH-Mutant Glioma (Grade 2-3) — Maximal safe resection; vorasidenib (Voranigo) for IDH1/2-mutant grade 2 glioma; radiation + PCV or temozolomide for grade 3; CCND2 amplification; 1p/19q codeletion (oligodendroglioma)
• Pediatric Brain Tumors — Medulloblastoma; ependymoma; DIPG/DMSG; coordination with pediatric oncology; BRAF V600E inhibitors for BRAF-mutated pediatric glioma; ONC201 for H3K27M-mutant DIPG
• Intraoperative Technologies — iMRI for real-time resection assessment; 5-ALA fluorescence for GBM; neuronavigation (Brainlab, Stryker); IONM (MEP, SEP, language mapping); awake craniotomy with cortical and subcortical mapping; ultrasound-guided surgery

Meningioma

• Surgical Resection — Simpson grade I-II resection for convexity and parasagittal meningiomas; skull base meningioma surgery (sphenoid wing, cavernous sinus, petroclival, foramen magnum); endoscopic-assisted resection
• Radiosurgery — Gamma Knife for small-medium meningiomas; WHO grade I observation vs. treatment; WHO grade II-III adjuvant radiation
• Medical Therapy — Somatostatin analogues for recurrent meningioma; pembrolizumab for high-grade meningioma; clinical trial access

Pituitary Tumors

• Endoscopic Transsphenoidal Surgery — Fully endoscopic endonasal transsphenoidal approach; extended transsphenoidal for suprasellar extension; one of Shanghai's most experienced pituitary surgery programs; coordination with endocrinology for hormonal management
• Acromegaly — Transsphenoidal surgery; somatostatin analogues (octreotide LAR, lanreotide); pegvisomant; pasireotide; Gamma Knife for residual tumor
• Cushing's Disease — Transsphenoidal surgery; Gamma Knife; ketoconazole; metyrapone; osilodrostat; bilateral adrenalectomy coordination
• Prolactinoma — Dopamine agonists (cabergoline) as first-line; surgery for resistant cases; Gamma Knife
• Non-Functioning Pituitary Adenoma — Observation for microadenomas; surgery for macroadenomas with mass effect; Gamma Knife for residual tumor
• Craniopharyngioma — Endoscopic transsphenoidal and transcranial approaches; BRAF V600E + MEK inhibitor for papillary craniopharyngioma; intracystic interferon for adamantinomatous

Skull Base Surgery

• Acoustic Neuroma (Vestibular Schwannoma) — Retrosigmoid, translabyrinthine, and middle fossa approaches; hearing preservation surgery; facial nerve monitoring and preservation; Gamma Knife for small-medium tumors; observation for elderly patients
• Chordoma & Chondrosarcoma — Endoscopic endonasal and open skull base approaches; proton beam therapy coordination for residual tumor
• Glomus Tumors — Surgical resection; embolization; Gamma Knife
• Epidermoid & Dermoid Cysts — Microsurgical resection; endoscopic-assisted resection

Brain Metastases

• Surgical Resection — For large symptomatic metastases; single and multiple metastases; en bloc resection; cavity SRS after resection
• Stereotactic Radiosurgery (SRS) — Gamma Knife for 1-10 brain metastases; single-fraction and fractionated SRS; WBRT with hippocampal avoidance for multiple metastases
• Systemic Therapy Integration — Targeted therapy for EGFR, ALK, BRAF, HER2 brain metastases; immunotherapy; coordination with oncology

Cerebrovascular Surgery

Intracranial Aneurysms

• Microsurgical Clipping — For ruptured and unruptured aneurysms; pterional, orbitozygomatic, and interhemispheric approaches; intraoperative angiography; ICG videoangiography; one of Shanghai's most experienced aneurysm clipping programs
• Endovascular Coiling — Coordination with neurointerventional radiology; coiling; stent-assisted coiling; balloon-assisted coiling; flow diversion (Pipeline embolization device)
• Subarachnoid Hemorrhage (SAH) — Early treatment within 24-72 hours; vasospasm management; nimodipine; endovascular vasospasm treatment; external ventricular drain (EVD); ventriculoperitoneal shunt for hydrocephalus

Arteriovenous Malformations (AVM)

• Microsurgical Resection — For Spetzler-Martin grade I-III AVMs; preoperative embolization; intraoperative monitoring
• Gamma Knife Radiosurgery — For small-medium AVMs in eloquent areas; 3-year obliteration rates
• Embolization — Preoperative embolization; palliative embolization for large AVMs; Onyx and NBCA liquid embolic agents

Cavernous Malformations

• Microsurgical resection for symptomatic cavernomas; brainstem cavernoma surgery; Gamma Knife for deep-seated lesions

Moyamoya Disease

• Revascularization Surgery — Direct bypass (STA-MCA); indirect bypass (EDAS, EMS, EMAS); combined direct and indirect bypass; one of Shanghai's most experienced Moyamoya surgery programs

Intracerebral Hemorrhage (ICH)

• Minimally invasive endoscopic ICH evacuation; stereotactic aspiration; craniotomy for large hematomas with mass effect; coordination with neurology for medical management

Functional Neurosurgery

• Deep Brain Stimulation (DBS) — STN and GPi DBS for Parkinson's disease; VIM DBS for essential tremor; GPi DBS for dystonia; awake and asleep DBS; adaptive DBS (aDBS); one of Shanghai's most experienced DBS programs; coordination with neurology
• MR-Guided Focused Ultrasound (MRgFUS) — Non-invasive thalamotomy for essential tremor and tremor-dominant PD; no implant; no incision; immediate tremor relief
• Epilepsy Surgery — Video-EEG monitoring; SEEG (stereoelectroencephalography) for invasive monitoring; cortical resection; temporal lobectomy; hemispherectomy; corpus callosotomy; VNS; RNS (NeuroPace); laser interstitial thermal therapy (LITT) for MRI-guided ablation
• Trigeminal Neuralgia — Microvascular decompression (MVD); Gamma Knife radiosurgery; percutaneous procedures (balloon compression, glycerol rhizotomy, RF thermocoagulation)
• Spasticity Management — Intrathecal baclofen pump (ITB); selective dorsal rhizotomy (SDR) for cerebral palsy spasticity

Gamma Knife Radiosurgery

• Indications — Brain metastases; meningioma; acoustic neuroma; AVM; pituitary adenoma; trigeminal neuralgia; cavernous malformation; recurrent glioma
• Technology — Leksell Gamma Knife Icon; frameless and frame-based treatment; hypofractionated SRS; one of Shanghai's most experienced Gamma Knife programs

Why International Patients Choose Shanghai First People's Hospital Neurosurgery

• Intraoperative MRI (iMRI) — Real-time resection assessment during brain tumor surgery; maximizes extent of resection while preserving function
• Vorasidenib for IDH-Mutant Glioma — First oral targeted therapy for IDH1/2-mutant grade 2 glioma; INDIGO trial evidence
• MRgFUS for Tremor — Non-invasive focused ultrasound thalamotomy; no surgery; immediate tremor relief
• Moyamoya Surgery — One of Shanghai's most experienced combined direct and indirect bypass programs
• SEEG Epilepsy Surgery — Stereoelectroencephalography for precise seizure focus localization; minimally invasive
• Cost-Effectiveness — World-class neurosurgical care at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your neurosurgical diagnosis, MRI/CT brain imaging, pathology reports, and prior treatment history with CMCS.
2. Medical Record Preparation — We translate and organize your records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate neurosurgeon based on your condition — brain tumor, cerebrovascular, functional neurosurgery, pituitary, skull base, or spinal neurosurgery.
4. MDT Submission — We facilitate pre-arrival case review by the multidisciplinary neuro-oncology tumor board.
5. Priority Scheduling — We secure a consultation with minimal waiting time.
6. Travel & Logistics — Assistance with visa invitation letters, accommodation near Shanghai First People's Hospital, and Shanghai airport transfers.
7. Surgical Coordination — Full coordination of pre-operative imaging, surgical admission, and post-operative neurological care.
8. Post-Operative Follow-Up — Surgical report translation, pathology result interpretation, adjuvant therapy coordination, and remote follow-up after you return home.

Book a Consultation

If you have a brain tumor, cerebral aneurysm, AVM, Parkinson's disease, epilepsy, trigeminal neuralgia, or a complex neurosurgical condition — CMCS can arrange a specialist consultation with Shanghai First People's Hospital's neurosurgery team.

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