Gynecologic Endocrinology at Fudan University Obstetrics & Gynecology Hospital | CMCS

Expert Female Hormonal Health at China's Premier Women's Hospital

The Department of Gynecologic Endocrinology at Fudan University Obstetrics and Gynecology Hospital (Red House Hospital / 红房子医院) — affiliated with Fudan University — is one of China's most distinguished gynecologic endocrinology centers, with a national reputation for excellence in polycystic ovary syndrome (PCOS), menstrual disorders, premature ovarian insufficiency, menopause management, adolescent gynecology, and the management of complex female hormonal conditions. As China's premier dedicated women's hospital, the department combines outstanding clinical expertise with a world-class research program, offering international patients access to some of China's most eminent gynecologic endocrinologists. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international patients throughout their hormonal health journey.

About the Department

The gynecologic endocrinology department is a national key clinical specialty operating a comprehensive hormonal health clinic, a PCOS center, a menopause clinic, an adolescent gynecology clinic, a premature ovarian insufficiency program, a hyperandrogenism clinic, and works in close collaboration with reproductive medicine, endocrinology, dermatology, and psychology through a fully integrated multidisciplinary team.

Polycystic Ovary Syndrome (PCOS)

Fudan University OB/GYN Hospital's PCOS program is one of China's most comprehensive:

Diagnosis & Assessment

• Rotterdam Criteria — Oligo/anovulation; clinical or biochemical hyperandrogenism; polycystic ovarian morphology (PCOM) on ultrasound; two of three criteria required; exclusion of other causes
• Hormonal Assessment — LH/FSH ratio; total and free testosterone; DHEAS; androstenedione; SHBG; free androgen index (FAI); AMH (elevated in PCOS); prolactin; thyroid function; 17-OHP (to exclude CAH)
• Metabolic Assessment — Fasting glucose and insulin; HOMA-IR; OGTT; HbA1c; lipid profile; blood pressure; BMI; waist circumference; visceral adiposity
• PCOS Phenotyping — Phenotype A (classic): anovulation + hyperandrogenism + PCOM; Phenotype B: anovulation + hyperandrogenism; Phenotype C: hyperandrogenism + PCOM; Phenotype D (ovulatory): anovulation + PCOM; treatment stratification by phenotype

Treatment

• Lifestyle Modification — Weight loss (5-10% reduces androgen levels and restores ovulation); low glycemic index diet; exercise; behavioral support; one of China's most comprehensive PCOS lifestyle programs
• Menstrual Regulation — Combined oral contraceptives (COC) for cycle regulation and hyperandrogenism; progestin withdrawal; LNG-IUD for endometrial protection
• Hyperandrogenism Treatment — COC (ethinyl estradiol + cyproterone acetate — Diane-35; drospirenone — Yasmin/Yaz); spironolactone; flutamide; finasteride; eflornithine for hirsutism; laser hair removal coordination
• Insulin Sensitizers — Metformin for metabolic PCOS; inositol (myo-inositol + D-chiro-inositol); pioglitazone for insulin-resistant PCOS; SGLT2 inhibitors for PCOS with obesity and metabolic syndrome
• Ovulation Induction — Letrozole (first-line — LEGRO trial); clomiphene citrate; metformin + letrozole; gonadotropins (FSH/hMG) for clomiphene/letrozole-resistant PCOS; laparoscopic ovarian drilling (LOD) for gonadotropin-resistant PCOS; coordination with reproductive medicine for IVF
• GLP-1 Receptor Agonists — Semaglutide (Ozempic/Wegovy) for PCOS with obesity; liraglutide; weight loss; improved insulin sensitivity; androgen reduction; menstrual regularity; one of China's most experienced GLP-1 agonist PCOS programs
• Long-Term Health — Endometrial cancer prevention (progestin/COC); cardiovascular risk reduction; T2DM prevention; psychological support

Menstrual Disorders

Abnormal Uterine Bleeding (AUB)

• PALM-COEIN Classification — Structural causes (polyp, adenomyosis, leiomyoma, malignancy); non-structural causes (coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, not classified)
• Heavy Menstrual Bleeding (HMB) — Tranexamic acid; NSAIDs; COC; LNG-IUD (Mirena — most effective medical treatment); GnRH antagonists (elagolix, relugolix); endometrial ablation; hysteroscopic myomectomy/polypectomy; coordination with minimally invasive gynecology
• Irregular Bleeding — Ovulatory dysfunction; progestin therapy; COC; endometrial biopsy for women >45 or with risk factors

Amenorrhea

• Primary Amenorrhea — Chromosomal evaluation (Turner syndrome — 45,X; Swyer syndrome — 46,XY); anatomical evaluation (Müllerian agenesis — MRKH syndrome; imperforate hymen; transverse vaginal septum); hypothalamic-pituitary evaluation; hormone replacement therapy; surgical correction; one of China's most experienced primary amenorrhea programs
• Secondary Amenorrhea — Hypothalamic amenorrhea (functional — weight loss, exercise, stress); hyperprolactinemia; thyroid disease; PCOS; POI; Asherman's syndrome; kisspeptin for hypothalamic amenorrhea; pulsatile GnRH therapy
• Hypothalamic Amenorrhea — Nutritional rehabilitation; weight restoration; reduction of exercise; psychological support; pulsatile GnRH for ovulation induction; kisspeptin; coordination with reproductive medicine

Dysmenorrhea

• Primary Dysmenorrhea — NSAIDs (naproxen, ibuprofen, mefenamic acid); COC; LNG-IUD; heat therapy; transcutaneous electrical nerve stimulation (TENS)
• Secondary Dysmenorrhea — Endometriosis; adenomyosis; fibroids; IUD-related; treatment of underlying cause; coordination with minimally invasive gynecology

Premature Ovarian Insufficiency (POI)

Fudan University OB/GYN Hospital's POI program is one of China's most comprehensive:

• Diagnosis — FSH >25 IU/L on two occasions >4 weeks apart before age 40; AMH; AFC; karyotype; FMR1 premutation; autoimmune evaluation (anti-ovarian antibodies, thyroid, adrenal); bone density (DXA)
• Hormone Replacement Therapy (HRT) — Estrogen + progestogen until natural menopause age (51 years); transdermal estradiol preferred (lower VTE risk); micronized progesterone; dydrogesterone; LNG-IUD for progestogen component; one of China's most experienced POI HRT programs
• Fertility — Spontaneous pregnancy possible (5-10%); donor oocyte IVF for most patients; fertility preservation before POI progression; coordination with reproductive medicine
• Bone Health — Calcium + vitamin D; weight-bearing exercise; HRT as primary bone protection; bisphosphonates if HRT contraindicated; DXA monitoring
• Cardiovascular Health — HRT reduces cardiovascular risk in POI; lipid monitoring; blood pressure; lifestyle modification
• Psychological Support — Counseling; support groups; sexual health; coordination with psychology
• Genetic Counseling — FMR1 premutation; Turner mosaic; autosomal dominant POI genes; family implications

Menopause Management

• Menopause Assessment — Symptom evaluation (Greene Climacteric Scale; MRS); cardiovascular risk; bone density (DXA); breast assessment; endometrial assessment; lipid profile; glucose
• Menopausal Hormone Therapy (MHT) — Estrogen + progestogen for women with uterus; estrogen alone for hysterectomized women; transdermal estradiol (lower VTE and stroke risk vs. oral); micronized progesterone (lower breast cancer risk vs. synthetic progestogens); dydrogesterone; tibolone; one of China's most experienced MHT programs
• Vasomotor Symptoms — MHT (most effective); fezolinetant (NK3 receptor antagonist — Veozah) for women who cannot or prefer not to use MHT; elinzanetant; SSRIs/SNRIs (venlafaxine, paroxetine); gabapentin; oxybutynin
• Genitourinary Syndrome of Menopause (GSM) — Vaginal estrogen (estriol, estradiol); ospemifene (SERM); prasterone (intravaginal DHEA — Intrarosa); laser therapy (CO2 laser, Er:YAG) for vaginal atrophy; one of China's most experienced GSM treatment programs
• Bone Health — MHT for bone protection; bisphosphonates (alendronate, zoledronic acid); denosumab; romosozumab for high-risk osteoporosis; DXA monitoring
• Cardiovascular Health — MHT timing hypothesis (window of opportunity); lipid management; blood pressure; lifestyle modification; coordination with cardiology
• Cognitive Health — MHT and dementia risk; sleep optimization; cognitive training; coordination with neurology

Adolescent Gynecology

• Pubertal Disorders — Precocious puberty (central — GnRH agonist; peripheral — treat cause); delayed puberty (constitutional; Turner syndrome; hypogonadotropic hypogonadism); coordination with pediatric endocrinology
• Adolescent PCOS — Diagnosis challenges in adolescence; lifestyle modification; COC; metformin; long-term follow-up
• Adolescent Endometriosis — Often underdiagnosed; COC; progestins; laparoscopic diagnosis and treatment; one of China's most experienced adolescent endometriosis programs
• Müllerian Anomalies — MRKH syndrome; uterine septum; bicornuate uterus; vaginal agenesis; vaginal dilation therapy; surgical correction; coordination with minimally invasive gynecology
• Androgen Insensitivity Syndrome (AIS) — Complete and partial AIS; gonadectomy timing; HRT; psychological support; genetic counseling
• Differences of Sex Development (DSD) — Multidisciplinary DSD team; genetic evaluation; hormonal management; surgical planning; psychological support

Hyperandrogenism

• Causes — PCOS (most common); non-classical CAH (21-hydroxylase deficiency); androgen-secreting tumors; Cushing's syndrome; idiopathic hyperandrogenism; drug-induced
• Assessment — Total and free testosterone; DHEAS; androstenedione; 17-OHP (ACTH stimulation test for CAH); cortisol; adrenal and ovarian imaging; adrenal vein sampling for tumor localization
• Treatment — COC; spironolactone; flutamide; finasteride; hydrocortisone for CAH; surgical resection for androgen-secreting tumors; coordination with endocrinology

Why International Patients Choose Fudan University OB/GYN Hospital Gynecologic Endocrinology

• Comprehensive PCOS Program — One of China's most experienced PCOS programs; GLP-1 agonist therapy; letrozole ovulation induction; metabolic management
• Fezolinetant for Menopause — NK3 receptor antagonist (Veozah) for vasomotor symptoms; non-hormonal option for women who cannot use MHT
• Prasterone & Ospemifene for GSM — Intravaginal DHEA and SERM for genitourinary syndrome of menopause
• POI Expertise — One of China's most experienced POI programs; transdermal HRT; fertility coordination; bone and cardiovascular protection
• Adolescent Gynecology — One of China's most experienced adolescent endometriosis and DSD programs
• Cost-Effectiveness — World-class gynecologic endocrinology care at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your hormonal health concerns, menstrual history, hormonal test results, and prior treatment history with CMCS.
2. Medical Record Preparation — We translate and organize your records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate gynecologic endocrinologist based on your condition — PCOS, menstrual disorders, amenorrhea, POI, menopause, adolescent gynecology, or hyperandrogenism.
4. Priority Scheduling — We secure a consultation with minimal waiting time.
5. Travel & Logistics — Assistance with visa invitation letters, accommodation near Fudan University OB/GYN Hospital, and Shanghai airport transfers.
6. Diagnostic Assessment — Full coordination of hormonal testing, ultrasound, DXA, and other required investigations.
7. Treatment Coordination — Full coordination of medication initiation, ovulation induction monitoring, or HRT optimization.
8. Post-Consultation Follow-Up — Test result translation, treatment plan interpretation, and remote follow-up coordination after you return home.

Book a Consultation

If you have PCOS, menstrual disorders, premature ovarian insufficiency, menopausal symptoms, adolescent gynecologic concerns, or any female hormonal health condition — CMCS can arrange a specialist consultation with Fudan University OB/GYN Hospital's gynecologic endocrinology team in Shanghai.

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