Endocrinology & Diabetes at Shanghai Sixth People's Hospital | CMCS

Expert Endocrine & Diabetes Care at One of China's Premier Academic Medical Centers

The Department of Endocrinology and Metabolism at Shanghai Sixth People's Hospital — affiliated with Shanghai Jiao Tong University School of Medicine — is one of China's most distinguished endocrinology centers, with a national reputation for excellence in diabetes management, thyroid disease, osteoporosis, pituitary disorders, adrenal disease, and the management of complex endocrine conditions. The department is particularly renowned for its diabetic foot program — a nationally recognized center of excellence that uniquely integrates endocrinology, vascular surgery, orthopedics, and the hospital's world-leading microsurgery program to deliver comprehensive limb-salvage care for patients with severe diabetic foot complications. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international patients throughout their endocrine care journey at Shanghai Sixth People's Hospital.

About the Department

The endocrinology department is a national key clinical specialty operating a comprehensive endocrinology clinic, a diabetes center with continuous glucose monitoring and insulin pump therapy, a diabetic foot clinic, a thyroid disease clinic, an osteoporosis center, a pituitary and adrenal disease clinic, an obesity and metabolic disease program, and works in close collaboration with vascular surgery, orthopedics, replantation and microsurgery, nephrology, cardiology, and ophthalmology through a fully integrated multidisciplinary team.

Diabetes Management

Type 1 Diabetes

• Intensive Insulin Therapy — Multiple daily injections (MDI); basal-bolus regimens; insulin pump therapy (CSII); closed-loop systems (artificial pancreas — MiniMed 780G, Omnipod 5)
• Continuous Glucose Monitoring (CGM) — Dexcom G7; FreeStyle Libre 3; Medtronic Guardian 4; time-in-range (TIR) optimization; hypoglycemia prevention
• Islet Transplantation — For brittle T1DM with recurrent severe hypoglycemia; coordination with transplant medicine
• Immunotherapy — Teplizumab for stage 2 T1DM (delay of clinical onset); clinical trial access

Type 2 Diabetes

• Lifestyle & Medical Management — Individualized HbA1c targets; metformin; SGLT2 inhibitors (empagliflozin, dapagliflozin, canagliflozin) for cardiovascular and renal protection; GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide, tirzepatide) for weight loss and CV benefit; DPP-4 inhibitors; sulfonylureas; insulin
• Tirzepatide (Mounjaro) — Dual GIP/GLP-1 receptor agonist; superior HbA1c reduction and weight loss; SURPASS trial evidence
• Semaglutide (Ozempic/Wegovy) — Weekly subcutaneous injection; SUSTAIN and STEP trial evidence; cardiovascular benefit (LEADER, SUSTAIN-6)
• Retatrutide — Triple GIP/GLP-1/glucagon receptor agonist; investigational; clinical trial access
• Metabolic Surgery — Roux-en-Y gastric bypass; sleeve gastrectomy for T2DM with BMI >27.5 in Asians; coordination with bariatric surgery
• Advanced Insulin Therapy — Degludec (Tresiba); glargine U300 (Toujeo); ultra-rapid insulin (Fiasp, Lyumjev); insulin pump therapy

Diabetic Complications

• Diabetic Nephropathy — SGLT2 inhibitors (dapagliflozin — DAPA-CKD; empagliflozin — EMPA-KIDNEY); finerenone (Kerendia) for CKD with T2DM; ACE inhibitors/ARBs; coordination with nephrology
• Diabetic Retinopathy — Glycemic and blood pressure control; anti-VEGF coordination with ophthalmology; laser photocoagulation; vitrectomy coordination
• Diabetic Neuropathy — Glycemic optimization; pregabalin; duloxetine; alpha-lipoic acid; benfotiamine; spinal cord stimulation for refractory painful neuropathy
• Diabetic Cardiomyopathy — SGLT2 inhibitors; GLP-1 agonists; coordination with cardiology

Diabetic Foot Program

Shanghai Sixth People's Hospital's diabetic foot program is one of China's most comprehensive and nationally recognized, uniquely integrating endocrinology with vascular surgery, orthopedics, and the hospital's world-leading microsurgery program:

• Diabetic Foot Assessment — Wagner and Texas classification; ABI and TBI measurement; transcutaneous oxygen pressure (TcPO2); CT angiography; MRI for osteomyelitis; neuropathy assessment (monofilament, vibration, NCS)
• Wound Management — Debridement; negative pressure wound therapy (NPWT); advanced wound dressings; offloading (total contact cast, removable cast walker); hyperbaric oxygen therapy
• Vascular Intervention — Endovascular revascularization (PTA, stenting) for peripheral arterial disease; bypass surgery for long-segment occlusions; coordination with vascular surgery
• Infection Management — Culture-directed antibiotics; surgical debridement; osteomyelitis management; biofilm disruption
• Microsurgical Reconstruction — Free flap coverage for large diabetic foot defects after revascularization; coordination with replantation and microsurgery department — unique capability not available at most centers
• Orthopedic Intervention — Charcot foot management; offloading; surgical reconstruction for Charcot deformity; coordination with orthopedics
• Limb Salvage Rate — One of China's highest diabetic foot limb salvage rates through multidisciplinary integration

Thyroid Disease

• Hypothyroidism — Levothyroxine; liothyronine combination therapy; TSH target optimization; subclinical hypothyroidism management
• Hyperthyroidism & Graves' Disease — Antithyroid drugs (methimazole, propylthiouracil); radioactive iodine (RAI) therapy; thyroidectomy coordination; Graves' ophthalmopathy management (teprotumumab; orbital decompression coordination)
• Thyroid Nodules & Cancer — Ultrasound-guided FNA; TIRADS classification; molecular testing (ThyroSeq, Afirma); active surveillance for low-risk PTC; coordination with thyroid surgery; RAI for differentiated thyroid cancer; lenvatinib and sorafenib for RAI-refractory DTC; selpercatinib for RET-mutated MTC
• Thyroiditis — Hashimoto's thyroiditis; subacute thyroiditis; postpartum thyroiditis; painless thyroiditis

Osteoporosis & Metabolic Bone Disease

Shanghai Sixth People's Hospital's osteoporosis program is one of China's most comprehensive, with particular expertise in fracture prevention and anabolic therapy:

• Osteoporosis Diagnosis — DXA bone density; TBS (trabecular bone score); FRAX fracture risk assessment; vertebral fracture assessment (VFA); bone turnover markers (CTX, P1NP)
• Antiresorptive Therapy — Bisphosphonates (alendronate, risedronate, zoledronic acid); denosumab (Prolia) for high-risk osteoporosis; romosozumab (Evenity) sequential therapy
• Anabolic Therapy — Teriparatide (Forteo) for severe osteoporosis; abaloparatide; romosozumab (Evenity — dual anabolic/antiresorptive) for very high fracture risk; sequential therapy planning
• Secondary Osteoporosis — Glucocorticoid-induced osteoporosis; hypogonadism; malabsorption; vitamin D deficiency; hyperparathyroidism
• Osteogenesis Imperfecta — Bisphosphonates; setrusumab (anti-sclerostin) for OI; coordination with orthopedics for fracture management

Pituitary & Adrenal Disease

• Acromegaly — Transsphenoidal surgery coordination; somatostatin analogues (octreotide LAR, lanreotide); pegvisomant; pasireotide; IGF-1 monitoring
• Cushing's Disease — Transsphenoidal surgery coordination; ketoconazole; metyrapone; osilodrostat; mifepristone; bilateral adrenalectomy coordination
• Prolactinoma — Dopamine agonists (cabergoline, bromocriptine); surgery for resistant cases
• Hypopituitarism — Hormone replacement (hydrocortisone, levothyroxine, sex steroids, growth hormone); dynamic testing
• Primary Hyperaldosteronism (Conn's Syndrome) — Adrenal vein sampling; adrenalectomy coordination; mineralocorticoid receptor antagonists (spironolactone, eplerenone)
• Pheochromocytoma & Paraganglioma — Alpha-blockade before surgery; adrenalectomy coordination; SDHB/SDHD genetic testing; Lu-177 DOTATATE for metastatic disease
• Adrenal Incidentaloma — Hormonal workup; imaging characterization; surveillance vs. adrenalectomy decision

Obesity & Metabolic Disease

• Medical Weight Management — Semaglutide (Wegovy); tirzepatide (Zepbound); liraglutide (Saxenda); orlistat; behavioral intervention; very low calorie diet (VLCD)
• Bariatric Surgery Coordination — Pre-operative endocrine assessment; post-operative nutritional monitoring; dumping syndrome management; hypoglycemia after bypass
• Metabolic Syndrome — Comprehensive cardiovascular risk reduction; SGLT2 inhibitors; GLP-1 agonists; statin therapy; blood pressure management
• Non-Alcoholic Fatty Liver Disease (MASLD) — Resmetirom; semaglutide; lifestyle intervention; coordination with hepatology

Why International Patients Choose Shanghai Sixth People's Hospital Endocrinology

• Diabetic Foot Center of Excellence — One of China's highest limb salvage rates; unique integration of endocrinology + vascular surgery + microsurgery for complex diabetic foot
• Closed-Loop Insulin Systems — MiniMed 780G and Omnipod 5 artificial pancreas for T1DM management
• Anabolic Osteoporosis Therapy — Romosozumab and teriparatide for severe osteoporosis; sequential therapy planning
• Tirzepatide & Retatrutide — Access to latest incretin-based therapies for T2DM and obesity
• Pheochromocytoma Expertise — Comprehensive workup and surgical coordination; Lu-177 DOTATATE for metastatic disease
• Cost-Effectiveness — World-class endocrine care at significantly lower cost than equivalent treatment in Western countries

The CMCS Patient Journey

1. Initial Inquiry — Share your endocrine diagnosis, laboratory results, imaging, current medications, and prior treatment history with CMCS.
2. Medical Record Preparation — We translate and organize your records for specialist pre-consultation review.
3. Specialist Matching — We identify the most appropriate endocrinologist based on your condition — diabetes, diabetic foot, thyroid, osteoporosis, pituitary, adrenal, or obesity.
4. MDT Submission — For diabetic foot patients, we facilitate pre-arrival case review by the multidisciplinary diabetic foot team.
5. Priority Scheduling — We secure a consultation with minimal waiting time.
6. Travel & Logistics — Assistance with visa invitation letters, accessible accommodation near Shanghai Sixth People's Hospital, and Shanghai airport transfers.
7. On-Site Concierge — Bilingual coordinators accompany you throughout hospital visits, managing registration, translation, and communication.
8. Post-Consultation Follow-Up — Test result translation, treatment plan interpretation, medication guidance, and remote follow-up coordination after you return home.

Book a Consultation

If you have diabetes, a diabetic foot complication, thyroid disease, osteoporosis, a pituitary or adrenal condition, or a complex endocrine problem — CMCS can arrange a specialist consultation with Shanghai Sixth People's Hospital's endocrinology team.

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