Expert High-Risk Pregnancy & Fetal Medicine Care at China's Premier Obstetric Hospital
The Department of Maternal-Fetal Medicine at Fudan University Obstetrics and Gynecology Hospital (Red House Hospital / 红房子医院) — affiliated with Fudan University — is one of China's most distinguished maternal-fetal medicine centers, with a national reputation for excellence in high-risk pregnancy management, prenatal diagnosis, fetal medicine, twin and multiple pregnancy, and the management of complex obstetric conditions. As China's premier dedicated obstetric hospital, the department combines outstanding clinical expertise with a world-class research program, offering international patients access to some of China's most eminent maternal-fetal medicine specialists. China Medical Concierge Shanghai (CMCS) provides seamless end-to-end coordination for international patients throughout their high-risk pregnancy journey.
About the Department
The maternal-fetal medicine department is a national key clinical specialty operating dedicated high-risk obstetric wards, a fetal medicine unit with advanced ultrasound capability, a prenatal diagnosis center, a fetal therapy program, a multidisciplinary obstetric clinic, a labor and delivery unit with 24/7 obstetric anesthesia, a level III NICU, and works in close collaboration with reproductive medicine, gynecologic oncology, cardiology, nephrology, hematology, and neonatology through a fully integrated multidisciplinary team.
Prenatal Diagnosis & Screening
Non-Invasive Prenatal Testing (NIPT)
- NIPT/NIPS — Cell-free fetal DNA from maternal blood; trisomy 21, 18, 13; sex chromosome aneuploidies; microdeletion syndromes (22q11.2, 1p36, 5p, 15q11-13, 11q23); expanded NIPT panels; one of China's most experienced NIPT programs
- NIPT-Plus — Expanded panel including subchromosomal copy number variants (CNVs); genome-wide NIPT; increased detection of rare autosomal trisomies
- NIPT for High-Risk Pregnancies — Advanced maternal age; prior trisomy pregnancy; abnormal first trimester screen; IVF pregnancies; twin pregnancies (dichorionic)
Invasive Prenatal Diagnosis
- Chorionic Villus Sampling (CVS) — Transcervical and transabdominal; 10-13 weeks; rapid karyotype; chromosomal microarray; molecular testing; one of China's most experienced CVS programs
- Amniocentesis — 15-20 weeks; karyotype; chromosomal microarray (CMA); exome sequencing for structural anomalies; PCR for specific mutations; one of China's highest-volume amniocentesis programs
- Chromosomal Microarray Analysis (CMA) — SNP array; oligonucleotide array; copy number variant detection; regions of homozygosity (ROH); superior to karyotype for structural anomalies
- Fetal Exome Sequencing — For fetuses with structural anomalies and normal CMA; trio exome (fetus + parents); detection of de novo and inherited pathogenic variants; one of China's most experienced fetal exome programs
- Fetal Whole Genome Sequencing — For complex cases; investigational; clinical trial access
Fetal Ultrasound
- First Trimester Screening — NT measurement; nasal bone; ductus venosus; tricuspid regurgitation; combined first trimester screening (NT + biochemistry); cell-free DNA; one of China's most experienced NT programs
- Detailed Anomaly Scan — 18-22 weeks; systematic fetal anatomy survey; 3D/4D ultrasound; fetal echocardiography; Doppler assessment; one of China's most experienced fetal anomaly scan programs
- Fetal Echocardiography — For high-risk pregnancies (family history, maternal diabetes, teratogen exposure, abnormal NT, chromosomal anomaly); four-chamber view; outflow tracts; great vessels; arches; one of China's most experienced fetal echo programs
- Fetal MRI — For CNS anomalies (ventriculomegaly, corpus callosum agenesis, posterior fossa); abdominal anomalies; lung lesions; complementary to ultrasound
- Fetal Growth Assessment — Biometry; estimated fetal weight; growth velocity; Doppler (umbilical artery, MCA, ductus venosus); biophysical profile; NST
High-Risk Pregnancy Management
Hypertensive Disorders of Pregnancy
- Preeclampsia Prevention — First trimester screening (MAP + UtA PI + PlGF + PAPP-A); aspirin prophylaxis from 11-14 weeks for high-risk women; calcium supplementation
- Preeclampsia Management — Antihypertensives (labetalol, nifedipine, methyldopa); magnesium sulfate for severe preeclampsia and eclampsia prevention; delivery timing; one of China's most experienced preeclampsia management programs
- HELLP Syndrome — Intensive monitoring; delivery; corticosteroids; plasma exchange for refractory cases
- Chronic Hypertension in Pregnancy — Antihypertensive optimization; aspirin; fetal surveillance; delivery planning
Diabetes in Pregnancy
- Gestational Diabetes (GDM) — OGTT screening; dietary modification; blood glucose monitoring; insulin therapy; metformin; fetal surveillance; delivery planning; postpartum follow-up
- Pre-existing Diabetes — Pre-conception optimization (HbA1c <6.5%); insulin optimization; CGM; fetal surveillance; anomaly scan; fetal echocardiography; delivery planning; coordination with endocrinology
Twin & Multiple Pregnancy
- Dichorionic Diamniotic (DCDA) Twins — Growth surveillance; cervical length monitoring; preterm birth prevention; delivery planning; one of China's most experienced twin pregnancy programs
- Monochorionic Diamniotic (MCDA) Twins — Fortnightly ultrasound for TTTS surveillance; selective fetal growth restriction (sFGR) management; TAPS (twin anemia-polycythemia sequence); delivery planning at 36-37 weeks
- Twin-to-Twin Transfusion Syndrome (TTTS) — Quintero staging; fetoscopic laser photocoagulation (FLP) for stage II-IV TTTS; one of China's most experienced TTTS laser programs; amnioreduction for selected cases
- Monochorionic Monoamniotic (MCMA) Twins — Intensive surveillance; cord entanglement monitoring; delivery at 32-34 weeks
- Higher-Order Multiples — Selective fetal reduction; multifetal pregnancy reduction; counseling
Preterm Birth Prevention
- Cervical Length Screening — Transvaginal ultrasound cervical length at 18-24 weeks; short cervix management
- Progesterone — Vaginal progesterone for short cervix; 17-OHPC for prior preterm birth; oral dydrogesterone
- Cervical Cerclage — History-indicated; ultrasound-indicated; physical examination-indicated (rescue cerclage); McDonald and Shirodkar techniques; one of China's most experienced cerclage programs
- Arabin Pessary — For short cervix in singleton and twin pregnancies
- Antenatal Corticosteroids — Betamethasone for fetal lung maturation at 24-34 weeks; magnesium sulfate for neuroprotection at <32 weeks
Other High-Risk Conditions
- Placenta Previa & Accreta Spectrum — Ultrasound and MRI diagnosis; multidisciplinary delivery planning; interventional radiology (balloon occlusion, UAE); cell salvage; one of China's most experienced placenta accreta programs
- Fetal Growth Restriction (FGR) — Doppler surveillance; timing of delivery; neonatal preparation; coordination with NICU
- Antiphospholipid Syndrome (APS) — Aspirin + LMWH; hydroxychloroquine; fetal surveillance; delivery planning; coordination with hematology and rheumatology
- Autoimmune Disease in Pregnancy — SLE; RA; Sjögren's; anti-Ro/La antibodies and fetal heart block; hydroxychloroquine; coordination with rheumatology
- Cardiac Disease in Pregnancy — Modified WHO classification; multidisciplinary cardiac obstetric team; delivery planning; coordination with cardiology
- Renal Disease in Pregnancy — CKD; lupus nephritis; nephrotic syndrome; coordination with nephrology
- Hematological Conditions — Thalassemia; sickle cell disease; ITP; thrombocytopenia; VTE prophylaxis; coordination with hematology
Fetal Therapy
- Fetoscopic Laser Photocoagulation (FLP) — For TTTS stage II-IV; selective coagulation of anastomoses on placental surface; one of China's most experienced FLP programs; Solomon technique for complete dichorionization
- Intrauterine Transfusion (IUT) — For fetal anemia (Rh alloimmunization, parvovirus B19, TAPS); intravascular transfusion via umbilical vein; one of China's most experienced IUT programs
- Fetal Pleural Drainage — Thoracoamniotic shunting for fetal hydrothorax; pleural effusion drainage
- Amnioreduction — For polyhydramnios; TTTS palliation; symptom relief
- Selective Fetal Reduction — For discordant anomaly in twin pregnancy; higher-order multiples; intracardiac KCl injection; radiofrequency ablation (RFA) for monochorionic twins
Why International Patients Choose Fudan University OB/GYN Hospital Maternal-Fetal Medicine
- China's Premier Obstetric Hospital — Nationally recognized expertise; highest-volume obstetric program in Shanghai; comprehensive multidisciplinary team
- Fetal Exome Sequencing — One of China's most experienced fetal exome programs; trio exome for structural anomalies with normal CMA
- TTTS Laser Program — One of China's most experienced fetoscopic laser photocoagulation programs; Solomon technique
- Placenta Accreta Expertise — One of China's most experienced placenta accreta spectrum programs; multidisciplinary delivery planning
- First Trimester Preeclampsia Screening — Combined screening with PlGF + UtA PI + MAP; aspirin prophylaxis from 11-14 weeks
- Cost-Effectiveness — World-class maternal-fetal medicine at significantly lower cost than equivalent treatment in Western countries
The CMCS Patient Journey
- Initial Inquiry — Share your obstetric history, current pregnancy details, ultrasound reports, prenatal screening results, and medical conditions with CMCS.
- Medical Record Preparation — We translate and organize your records for specialist pre-consultation review.
- Specialist Matching — We identify the most appropriate maternal-fetal medicine specialist based on your condition — prenatal diagnosis, high-risk pregnancy, twin pregnancy, fetal anomaly, or fetal therapy.
- Priority Scheduling — We secure a consultation with minimal waiting time.
- Travel & Logistics — Assistance with visa invitation letters, accessible accommodation near Fudan University OB/GYN Hospital, and Shanghai airport transfers.
- Diagnostic Assessment — Full coordination of detailed anomaly scan, fetal echocardiography, amniocentesis, CMA, and fetal exome sequencing.
- Delivery Planning — Coordination of delivery admission, anesthesia planning, and NICU preparation for high-risk deliveries.
- Post-Delivery Follow-Up — Delivery report translation, neonatal result interpretation, and remote follow-up coordination after you return home.
Book a Consultation
If you have a high-risk pregnancy, require prenatal diagnosis, have a twin pregnancy, a fetal anomaly, or need fetal therapy — CMCS can arrange a specialist consultation with Fudan University OB/GYN Hospital's maternal-fetal medicine team in Shanghai.
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